Recombinant Human CXCL3/MIP2-beta/GRO Gamma

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 1.0 mg
Host E.coli
ArtNr CS-CRG504C
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Description
The three GRO cDNAs encode 107 amino acid precursor proteins from which the N-terminal 34 amino acid residues are cleaved to generate the mature GROs. There are no potential N-linked glycosylation sites in the amino acid sequences. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively.Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B. Recombinant Human GRO-gamma is a single non-glycosylated polypeptide chain containing 73 amino acids.
Formulation
Lyophilized from a 0.2um filtered concentrated solution in 20 mM PB, pH 7.4 + 50mM NaCl.
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.
GeneID
2921
Source
E. coli
Molecular Weight
7.9 kDa
Purity
>97% by HPLC and SDS-PAGE
Protein Accession No
NP_002081
Endotoxin Level
Less than 1EU/ug of rHuGRO-gamma/CXCL3 as determined by LAL method.
Biological Activity
Determined by its ability to chemoattract CXCR2 transfected 293 cells using a concentration range of 10.0-100.0 ng/mL.
AA Sequence
ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN
Menge: 1.0 mg
Lieferbar: In stock
Listenpreis: 2.151,47 €
Preis: 2.151,47 €
lieferbar

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