ArtNr |
CS-CRI254A |
Hersteller |
Cell Sciences
|
Menge |
10 ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Purity |
>95% by SDS-PAGE |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
T cell growth factor, aldesleukin, interleukin-2, involved in regulation of T-cell clonal expansion |
Lieferbar |
|
Biological Activity |
Bioactivity is assayed by measuring the dose dependent effect of human IL-2 on proliferation of CTLL-2 cells. The EC50 for a typical batch of recombinant human IL-2 is 1.08 ng/ml. |
Description |
Interleukin 2 (IL-2) is a potent immunoregulatory growth factor produced by T-cells following stimulation by mitogens or allogens. IL-2 promotes growth and differentiation of various cells of the immune system, such as activated T-cells and B-cells, NK cells, lymphokine activated killer cells, monocytes and macrophages. It is essential for proper immune response, it may also be an important factor in the natural suppression of autoimmunity. IL-2 may be of use as an anti-tumor agent in cancer therapy. Human and mouse IL-2 share 56% aa sequence identity and exhibit cross-species activity. The Recombinant Human IL-2 HQ contains 133 amino acids and a 16 a.a. histidine based tag for a total lenght of 149 a.a. |
Endotoxin Level |
<0.005 ng per ug of product (0.05 EU/ug) as measured by turbidimetric kinetic assay. |
Formulation |
Lyophilized from a 0.2 um sterile filtered solution of PBS, pH 7.2. |
Molecular Weight |
Predicted MW = 17.5 kDa. The recombinant protein migrates with an apparent MW = 22 kDa in SDS-PAGE. |
Reconstitution |
Centrifuge vial prior to opening. It is recommended to reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 ug/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). The optimal concentration should be determined by the user for each specific application. |
Storage and Stability |
The lyophilized protein, though stable at room temperature for few weeks, is best stored at -20C to -80C. Reconstituted protein should be used immediately or stored in working aliquots at -20C to -80C. Avoid repeated freeze-thaw cycles. |
Specificity |
>1 x 10E6 U/mg |
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