Recombinant Human IL-2 HQ

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 10 ug
ArtNr CS-CRI254A
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Interleukin 2 (IL-2) is a potent immunoregulatory growth factor produced by T-cells following stimulation by mitogens or allogens. IL-2 promotes growth and differentiation of various cells of the immune system, such as activated T-cells and B-cells, NK cells, lymphokine activated killer cells, monocytes and macrophages. It is essential for proper immune response, it may also be an important factor in the natural suppression of autoimmunity. IL-2 may be of use as an anti-tumor agent in cancer therapy. Human and mouse IL-2 share 56% aa sequence identity and exhibit cross-species activity. The Recombinant Human IL-2 HQ contains 133 amino acids and a 16 a.a. histidine based tag for a total lenght of 149 a.a.
Formulation
Lyophilized from a 0.2 um sterile filtered solution of PBS, pH 7.2.
Reconstitution
Centrifuge vial prior to opening. It is recommended to reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 ug/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). The optimal concentration should be determined by the user for each specific application.
Storage and Stability
The lyophilized protein, though stable at room temperature for few weeks, is best stored at -20C to -80C. Reconstituted protein should be used immediately or stored in working aliquots at -20C to -80C. Avoid repeated freeze-thaw cycles.
GeneID
3558
Source
Hordeum vulgare (barley grain). Barley grain exhibits up to 50 times less protease activity than, E. coli, or mammalian cells. Barley seed is void of any human or animal viral contaminants, which is ideal for cell culture and, in vitro, and, in vivo, biological experiments.
Molecular Weight
Predicted MW = 17.5 kDa. The recombinant protein migrates with an apparent MW = 22 kDa in SDS-PAGE.
Purity
>95% by SDS-PAGE
Specific Activity
>1 x 10E6 U/mg
Endotoxin Level
<0.005 ng per ug of product (0.05 EU/ug) as measured by turbidimetric kinetic assay.
Biological Activity
Bioactivity is assayed by measuring the dose dependent effect of human IL-2 on proliferation of CTLL-2 cells. The EC50 for a typical batch of recombinant human IL-2 is 1.08 ng/ml.

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Menge: 10 ug
Lieferbar: In stock
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