Vergleich

Recombinant Human IGFBP3

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 25 ug
Host E.coli
ArtNr CS-CRI504B
Targets IGFBP3, IGF1, INS, GH1
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Biological Activity
Fully biologically active when compared to standard. The ED50 determined by inhibiting IGF-II induced proliferation of serum free human MCF-7 cells is less than 200 ng/ml, corresponding to a specific activity of „ 5.0 ca. 103 IU/mg in the presence of 15 ng/ml of rHuIGF-II.
Description
Insulin-like Growth Factor-Binding Protein 3(IGF-BP3) is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in alpha-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF.
Endotoxin Level
Less than 1EU/ug of rHuIGF-BP3 as determined by LAL method.
Formulation
Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.
Molecular Weight
28.8 kDa
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <=-20C. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
Stable at 2-8C, but best kept desiccated -20C. Upon reconstitution, stable for up to 1 week at 2-8C. For longer term, store in working aliquots at -20C-80C. Avoid repeated freeze/thaw cycles.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 25 ug
Lieferbar: In stock
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Lieferung vsl. bis 18.04.2024 

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