Recombinant Human LAIR1

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 20 ug
Host E.coli
ArtNr CS-CRL109B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
LAIR1 is a glycoprotein (ca.32 kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region. LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. LAIR1 Recombinant produced in, E. coli, is a single, non-glycosylated polypeptide chain containing amino acids 105 and having a MW = 11.5 kDa. The extracellular domain of LAIR-1 (22-125 aa) was over expressed in, E. coli, .
Formulation
The protein (1 mg/ml) contains 20 mM Tris-HCl, (pH7.5) + 50 mM NaCl and 1 mM EDTA.
Storage and Stability
Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
GeneID
3903
Source
E. coli
Molecular Weight
11.5 kDa
Purity
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
AA Sequence
MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG.

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Menge: 20 ug
Lieferbar: In stock
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