Recombinant Human LAIR1

LAIR1 is a glycoprotein (ca.32 kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region. LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. LAIR1 Recombinant produced in, E. coli, is a single, non-glycosylated polypeptide chain containing amino acids 105 and having a MW = 11.5 kDa. The extracellular domain of LAIR-1 (22-125 aa) was over expressed in, E. coli, .

11.5 kDa