Recombinant Human Cytochrome P450 2D6

Kein Verkauf an Patienten, Ärzte, Apotheken oder Privatpersonen! Mehr erfahren

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Applikationen WB
Menge 20 ug
Host Insect
ArtNr CS-CRL308B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Applications
WB
Description
Cytochrome P450 2D6 is a member of a complex family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which perform detoxification reaction on xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1) which has been classically defined by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2, LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The International Autoimmune Hepatitis Group therefore has subdivided the AIH type 2 into two subgroups: 2a with HCV and 2b without HCV. AIH 2a patients are often over 40 and predominantly male. The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques. Recombinant Human Cytochrome P450 2D6, also called liver/kidney microsomal antigen 1 is produced in SF9 is a glycosylated, polypeptide chain having a MW of 55.801 kDa.
Formulation
Recombinant Human LKM 1 is supplied at a of 1 mg/ml in 16 mM sodium phosphate buffer pH 7.6, 400 mM sodium chloride, 0.08 mM Kl and 20% glycerol.
Source
Sf9 insect cells.
Purity
Greater than 40% (SDS-PAGE).

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt und Sicherheitsdatenblatt) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Menge: 20 ug
Lieferbar: In stock
lieferbar

Vergleichen

Auf den Wunschzettel

Lieferzeit anfragen

Technische Frage stellen

Bulk-Anfrage stellen

Fragen zum Produkt?
 
Schließen