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Recombinant Human MIC-A

ArtNr CS-CRM127C
Hersteller Cell Sciences
Menge 1.0 mg
Kategorie
Typ Proteins
Specific against Human (Homo sapiens)
Host E.coli
Purity >95% by SDS-PAGE and HPLC
Sequence MSYYHHHHHH DYDIPTTENL YFQGAMAPEF EPHSLRYNLT VLSWDGSVQS GFLTEVHLDG QPFLRCDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETKEWTMP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRRYLKSGVVLRR TVPPMVNVTR SEASEGNITV TCR
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products FLJ60820, MGC111087, PERB11.1, HLA class I antigen, MHC class I chain-related gene A protein, MHC class I chain-related protein A, Stress inducible class I homolog, OTTHUMP00000029088, OTTHUMP00000035033, OTTHUMP00000035034
Lieferbar
Manufacturer - Category
Biomolecules
Storage Conditions
Stable at 2-8C, but best kept desiccated -20C. Upon reconstitution, stable for up to 1 week at 2-8C. For longer term, store in working aliquots below -20C. Avoid repeated freeze/thaw cycles.
Molecular Weight
36 kDa
Description
MIC-A (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig-like domains, but they have no capacity to bind peptide or interact with beta2-microglobulin. The genes encoding these proteins are found within the Major Histocompatibility Complex on human chromosome 6. The MICA locus is highly polymorphic with more than 50 recognized human alleles. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. MICA is a ligand for human NKG2D, an activating receptor expressed on NK cells, NKT cells, gammadelta T cells, and CD8+ alphabeta T cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.
Formulation
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in appropriate buffered solutions.
Biological Activity
Fully biologically active when compared to standard. The specific activity is determined by binding MICA antibody in ELISA.
Endotoxin Level
Less than 1EU/ug of rHuMIC-A as determined by LAL method.

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Menge: 1.0 mg
Lieferbar: In stock
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Lieferung vsl. bis 07.08.2025 

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