Recombinant Human CCL18/MIP-4

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 1.0 mg
Host E.coli
ArtNr CS-CRM410C
eClass 6.1 34160400
eClass 9.0 42020190
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Description
CCL18 is a novel CC chemokine that is highly homologous to MIP-1alpha (61% amino acid sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. in vitro , CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10 and IL-13, and inhibited by IFN-gamma. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. in vivo , CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells, but not monocytes or neutrophils.
Formulation
Lyophilized from a 0.2 um filtered concentrated solution in 20 mM PB, pH 7.4 + 100 mM NaCl.
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
Stable at 2-8C, but best kept desiccated -20C. Upon reconstitution, stable for up to 1 week at 2-8C. For longer term, store in working aliquots below -20C. Avoid repeated freeze/thaw cycles.
GeneID
6362
Source
E. coli
Molecular Weight
7.8 kDa
Purity
>98% by SDS-PAGE and HPLC
Endotoxin Level
Less than 1 EU/ug of rHuMIP-4/CCL18 as determined by LAL method.
Biological Activity
Determined by its ability to chemoattract human T lymphocytes using a concentration of 1.0-10.0 ng/mL.
AA Sequence
AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA

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Menge: 1.0 mg
Lieferbar: In stock
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