Recombinant Human EXOSC10 His

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Hersteller Cell Sciences
Typ Proteins
Specific against Human
Menge 20 ug
Host Insect
ArtNr CS-CRP140B
eClass 6.1 34160400
eClass 9.0 42020190
Recombinant Human EXOSC10 is a glycosylated, polypeptide chain produced in a Bacuolvirus insect cell system and is expressed with a 6x His tag. EXOSC10 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes). Autoantibodies against EXOSC10 occur in patients suffering from polymyositis, scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM/Scl complex are positive for EXOSC10 antibodies, making this specificity an important marker. The presence of EXOSC10 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis that is seen when other myositis and systemic sclerosis-specific autoantibodies are present.
Sterile filtered clear solution containing 20 mM HEPES, pH-7.5, + 100 mM NaCl + 0.01 mM EDTA + 0.02% SDS
Storage and Stability
Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid multiple freeze-thaw cycles.
0.8 mg/ml
Sf9 insect cells
Molecular Weight
120 kDa
> 70% as determined by SDS-PAGE.

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Menge: 20 ug
Lieferbar: In stock


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