Vergleich

Recombinant Human EXOSC10 His

ArtNr CS-CRP140B
Hersteller Cell Sciences
Menge 20 ug
Kategorie
Typ Proteins
Specific against Human (Homo sapiens)
Host Insect
Konjugat/Tag His
Purity > 70% as determined by SDS-PAGE.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products p4, p3, p2, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, autoantigen PM-SCL, polymyositis/scleroderma autoantigen 2 (100kD), polymyositis/scleroderma autoantigen 2, 100kDa, OTTHUMP00000002176, OTTHUMP00000002177
Lieferbar
Manufacturer - Category
Biomolecules
Storage Conditions
Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight
120 kDa
Description
Recombinant Human EXOSC10 is a glycosylated, polypeptide chain produced in a Bacuolvirus insect cell system and is expressed with a 6x His tag. EXOSC10 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes). Autoantibodies against EXOSC10 occur in patients suffering from polymyositis, scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM/Scl complex are positive for EXOSC10 antibodies, making this specificity an important marker. The presence of EXOSC10 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis that is seen when other myositis and systemic sclerosis-specific autoantibodies are present.
Formulation
Sterile filtered clear solution containing 20 mM HEPES, pH-7.5, + 100 mM NaCl + 0.01 mM EDTA + 0.02% SDS
Concentration
0.8 mg/ml

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Menge: 20 ug
Lieferbar: In stock
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