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Recombinant Human PDGF-AB

Recombinant Human PDGF-AB

Hersteller	Cell Sciences
Kategorie	Oncology Metabolism Diabetes Glucose Homeostasis By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Senescence Astrocytoma By Organ Bladder Cancer Bone Cancer
Typ	Proteins
Specific against	Human
Menge	10 ug
Host	E.coli
ArtNr	CS-CRP301B
Targets	PDGFA, RB1
eClass 6.1	34160400
eClass 9.0	42020190
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Biological Activity	The activity is determined by the dose-dependent proliferation of mouse 3T3 indicator cells and is typically less than 1 ng/mL.
Description	Platelet-Derived Growth Factor (PDGF) is a mitogenic peptide growth hormone carried in the alpha-granules of platelets and is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication. The synthesis of PDGF can be induced by IL-1, IL-6, TNF-alpha, TGF-beta and EGF. Recombinant human PDGF-AB is a non-glycosylated, disulfide-linked heterodimer.
Endotoxin Level	Measured by kinetic LAL analysis and is typically <= 1 EU/ug protein.
Formulation	Recombinant human PDGF-AB is lyophilized from 10 mM acetic acid (AcOH).
Molecular Weight	one 13.3 kDa alpha-chain and one 12.2 kDa beta-chain, with total molecular weight of 25.5 kDa.
Reconstitution	Centrifuge vial prior to opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.
Storage and Stability	Lyophilized product is very stable at -20C. Reconstituted material should be aliquoted and frozen at -20C. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles.
Specificity	1.0 x 106 IU/mg

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