Recombinant Human Tissue Plasminogen Activator Active

Recombinant Human Tissue Plasminogen Activator is a 527 amino acid glycoprotein. The tPA is synthesized from cDNA from a human melanoma cell line and produced recombinantly in CHO cells. It is a fully active, >85% single chain. Tissue Plasminogen Activator (tPA/PLAT) is a secreted serine protease which converts the proenzyme Plasminogen to Plasmin, a fibrinolytic enzyme. tPA is synthesized as a single chain which is cleaved by Plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

70.0 kDa

593, 600 IU/mg (Relative to WHO International Standard for Human Recombinant Tissue Plasminogen Activator, NIBSC 98/714)