Recombinant Human TARS His

Store at 2-4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid multiple freeze-thaw cycles.

Threonyl-tRNA Synthetase catalyzes the aminoacylation of tRNA by their cognate amino acid. Because of the central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family. TARS is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that PL-7 antibodies, like Jo-1 antibodies, indicate an increased risk for lung involvement, but this needs to be confirmed for a larger number of cases. Recombinant Human Threonyl-tRNA Synthetase produced in Sf9 is a glycosylated, polypeptide chain having a MW = 83.3 kDa. The protein is expressed with a -6x His tag and purified by proprietary chromatographic techniques.