Vergleich

Recombinant Human Tissue Plasminogen Activator

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 100 ug
Host CHO cells
ArtNr CS-CSI12668
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Recombinant Human Tissue Plasminogen Activator produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a MW = 59 kDa. The tPA is purified by proprietary chromatographic techniques.
Endotoxin Level
< 0.1 ng/ug of TPA
Formulation
Lyophilized from a sterile filtered solution. Each mg of TPA contains 1.7 g L-arginine + 0.5 g phosphoric acid, and 4 mg Tween-80.
Molecular Weight
59 kDa
Reconstitution
Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability
Lyophilized t-PA although stable at room temperature for 3 weeks, should be stored desiccated ate -20C. Upon reconstitution tPA should be stored at 2-4C between 2-7 days and for future use aliquoted and stored at -20C to -80C.. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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Lieferung vsl. bis 18.04.2024 

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