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Recombinant Human UBC9 His

ArtNr CS-CSI12724
Hersteller Cell Sciences
Menge 50 ug
Kategorie
Typ Proteins
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag His
Purity >95% by SDS-PAGE and HPLC analyses.
Sequence MHHHHHHAMG TLNMSGIALS RLAQERKAWR KDHPFGFVAV PTKNPDGTMN LMNWECAIPG KKGTPWEGGL FKLRMLFKDD YPSSPPKCKF EPPLFHPNVY PSGTVCLSIL EEDKDWRPAI TIKQILLGIQ ELLNEPNIQD PAQAEAYTIY CQNRVEYEKR VRAQAKKFAP S
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products UBC9, P18, ubiquitin carrier protein, C358B7.1, SUMO-1-protein ligase, ubiquitin conjugating enzyme 9, ubiquitin-conjugating enzyme E2I, ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9), ubiquitin-conjugating enzyme UbcE2A, ubiquitin-like protein SUMO-1 conjugating enzyme, ubiquitin-protein ligase E2I
Lieferbar
Manufacturer - Category
Biomolecules
Storage Conditions
Stable for 1 year at -20C. Avoid repeated freeze/thaw cycles.
Molecular Weight
ca.19.5 kDa
Description
Ubiquitin Conjugating Enzyme 9 (UBC9) belongs to the ubiquitin-conjugating enzyme family and is encoded by the UBE2I gene in humans. The ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, take part in the second step in the ubiquitination reaction. In this reaction, E1 activates the ubiquitin by covalently attaching the molecule to its active site cysteine residue. The activated ubiquitin is then transferred to an E2 cysteine and then the E2 molecule binds E3 via a structurally conserved binding region. The UBC9 accepts the ubiquitin-like proteins SUMO1-4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Additionally, it takes part in the formation of poly-SUMO chains, sumoylation of FOXL2 and KAT5, and the segregation of nuclear architecture and chromosome. Recombinant Human UBC9 is a single non-glycosylated polypeptide chain containing 158 amino acids of human UBC9 and an 8 amino acid vector sequence including a 6X His-tag at the N-terminus.
Formulation
Sterile liquid in 50 mM HEPES + 125 mM NaCl + 1 mM DTT + 10% Glycerol, pH 7.6
Endotoxin Level
<1 EU/ug of protein as determined by LAL method

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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