Recombinant Mouse Stem Cell Factor

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Mouse
Menge 10 ug
Host E.coli
ArtNr CS-CRS201B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
C-kit ligand, the recently identified ligand for the kit tyrosine kinase receptor, is mapped to the mouse S1 locus. This pleiotropic cytokine, alternately known as stem cell factor (SCF), mast cell growth factor (MGF) and steel-factor (SLF), plays essential roles in gametogenesis, melanogenesis and early stages of hematopoiesis. in vitro, and, in vivo , SCF can stimulate the proliferation of mature, as well as the proliferation and maturation of immature, mast cells. On purified primitive human and mouse hematopoietic precursors, SCF acts in a synergistic manner with various growth factors, such as IL-1, IL-3, IL-6, IL-7, and Epo, to induce myeloid, erythroid and lymphoid lineage colony formation. The finding that SCF is also expressed in the nervous system suggests a possible role for SCF in the development of the nervous system.
Formulation
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
This lyophilized preparation is stable at 2-4C, but should be kept desiccated at -20C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -80C. Avoid repeated freeze/thaw cycles.
GeneID
17311
Source
E. coli
Molecular Weight
Approximately 18.4 kDa
Purity
>97% by SDS-PAGE and HPLC analyses.
Specific Activity
1 x 105 IU/mg
Endotoxin Level
Less than 1 EU/ug as determined by LAL method.
Biological Activity
The activity is determined by the dose-dependent proliferation of human TF-1 cells and is typically less than 10 ng/mL.
AA Sequence
MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA

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Menge: 10 ug
Lieferbar: In stock
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