Recombinant HTLV-I p24 Core

HTLV-1 p24 although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies). The, E. coli, derived recombinant protein contains the full-length sequence of HTLV-I p24, spanning all of p24. The protein contains 214 amino acids having an Mw of 24 kDa.

Immunoreactive with all sera of HTLV-1 infected individuals.