Recombinant HTLV-I + II

Protein is shipped at ambient temperature. Upon arrival, Store at -20C.

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cells called Th1 cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependent response (these include parasitic infections and production of mucosal and humoral antibodies). E. coli, derived recombinant 100 kDa protein, (Purified/Coating, EIA), strain: BL21 DE3.

It is recommended to reconstitute the lyophilized HTLV-1 Envelope in sterile 18MU-cm water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.