Recombinant Rat IL-6

The lyophilized product is stable for several weeks at 2-4C, but should be stored desiccated at -20C. After reconstitution, the protein should be divided into working aliquots and frozen at -80C. Avoid repeated freeze-thaw cycles.

Recombinant Rat IL-6 is a single, non-glycosylated polypeptide chain containing 187 amino acids. IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130.

Centrifuge vial prior to opening to bring contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

< 0.1 ng/ug of protein.