Tubulin inhibitor 1

2237054-53-2

C21H24N2O4

DMSO : >= 125 mg/mL (339.28 mM)

Cell Cycle/DNA Damage; Cytoskeleton; Apoptosis

Tubulin inhibitor 1 is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis^[1]. IC50 & Target: Tubulin^[1] In Vitro: Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization^[1].
Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC₅₀s of 16.7 +/- 3.0, 31.4 +/- 0.7, 32.8 +/- 2.9, 67.0 +/- 0.8, 58.0 +/- 2.4 and 35.4 +/- 5.6 nM, respectively^[1].
Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells^[1]. In Vivo: Tubulin inhibitor 1 (50 mg/kg, i.p., every two days three times for 20-25 days) is well tolerated, significantly reduces tumour growth in Balb/c nude mice bearing SK-OV-3 cells^[1].