(+)-Kavain

500-64-1

C14H14O3

DMSO : >= 125 mg/mL (542.86 mM)

Membrane Transporter/Ion Channel; Neuronal Signaling; Membrane Transporter/Ion Channel; Membrane Transporter/Ion Channel; Neuronal Signaling

(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na⁺ and Ca²⁺ channels^[1]. (+)-Kavain is shown to bind at the alpha4beta2delta GABA_A receptor and potentiate GABA efficacy^[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied^[4]. IC50 & Target: Na⁺, Ca²⁺ channel^[1].
alpha4beta2delta GABA_A receptor^[2]. In Vitro: (+)-Kavain (10-300 uM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170+/-23% of enhancement measured at 300 uM^[2]. (+)-Kavain inhibits TNF-alpha secretion in cells via suppression of LITAF^[4].