L-JNKI-1

C164H286N66O40

10 mM in DMSO

MAPK/ERK Pathway

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK. IC50 & Target: JNK^[1]. In Vivo: L-JNKI-1 has been shown to effectively inhibit JNK activity in in vivo studies. It is shown that Ang II induces a dose-dependent pressor response, which was significantly attenuated by JNK inhibition^[1]. It is also found that 10 uM L-JNKI-1 decreases phosphorylated c-Jun by 98% and phosphorylated Elk-1 by 100%. L-JNKI-1 is able to across the blood-brain barrier and penetrate neurons of adult mice and P5 rats within 1 h after an intraperitoneal injection^[2].