C-176

314054-00-7

C11H7IN2O4

DMSO : 150 mg/mL (418.89 mM; Need ultrasonic)

Immunology/Inflammation

C-176 is a strong and covalent mouse STING inhibitor. IC50 & Target: STING^[1]. In Vitro: C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNbeta reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6^[1]. In Vivo: Notably, treatment of Trex1^?/? mice with C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart. Wild-type mice on a two-week treatment with C-176 show no evident signs of overt toxicity. The three-month trial conducted with C-176 in Trex1^?/? mice demonstrates marked amelioration of various signs of systemic inflammation^[1].