Etoricoxib

202409-33-4

C18H15ClN2O2S

DMSO : 100 mg/mL (278.68 mM; Need ultrasonic)

Immunology/Inflammation

Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 uM and 116 uM for COX-2 and COX-1 in human whole blood. IC50 & Target: IC50: 1.1 uM (COX-2, in human whole blood), 116 uM (COX-1, in human whole blood)^[1] In Vitro: Etoricoxib (MK-0663) is a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 uM, 116 uM and 5 uM for COX-2, COX-1 in human whole blood and purified human COX-2, respectively. Etoricoxib (MK-0663) shows inhibitory effect on PGE2 production by CHO (COX-2) cells (IC₅₀, 79 nM), on purified human COX-2 with detergent (IC₅₀, 4.1 uM), and on purified PGE2 production by U937 microsomes (low substrate; IC₅₀, 12.1 uM). However, Etoricoxib (MK-0663) has little activity against COX-1 with a K_i of 167 uM^[1]. In Vivo: Etoricoxib (MK-0663) (0.1-30 mg/kg, p.o.) dose-dependently inhibits carrageenan-induced paw edema, carrageenan-induced paw hyperalgesia, and endotoxin-induced pyresis in rats. Etoricoxib (>=10 mg/kg) completely reverses hyperalgesia response in the rat hyperalgesia model. Etoricoxib (MK-0663) (200 mg/kg/day) has no effect on urinary ⁵¹Cr excretion in rats, and nor in monkeys at 100 mg/kg/day^[1]. Etoricoxib (MK-0663) (50 and 100?mg/kg) potently increases the malondialdehyde (MDA) and myeloperoxidase (MPO) levels, and decreases the total glutathione (tGSH) and glutathione reductase (GSHRd) levels in rats. Etoricoxib (MK-0663) (100?mg/kg) significantly inhibits the decrease of NO in rats^[2]. Etoricoxib (MK-0663) (0.64 mg/kg, p.o.) reduces the features such as multiple plaque lesions, hyperplasia and dysplasia induced by 1, 2-dimethylhydrazine dihydrochloride (DMH) in rats^[3].