DMOG

89464-63-1

C6H9NO5

DMSO : >= 101.5 mg/mL (579.54 mM); H2O : 50 mg/mL (285.49 mM; Need ultrasonic)

Autophagy; Metabolic Enzyme/Protease

DMOG (Dimethyloxallyl Glycine) is a cell-permeable and competitive inhibitor of HIF-1alpha prolyl hydroxylase (HIF-PH). IC50 & Target: HIF-1alpha prolyl hydroxylase^[1] In Vitro: DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system^[1]. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC^[3]. In Vivo: DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice^[2]. Up-regulation of hypoxia-inducible factor-1alpha by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats^[4].