ZM241385

139180-30-6

C16H15N7O2

DMSO : >= 30 mg/mL (88.93 mM)

GPCR/G Protein

ZM 241385 is a novel non-xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype. Target: adenosine receptor in vitro: ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52. [1] in vivo: ZM 241385 has low potency at A2b receptors and antagonized the relaxant effects of adenosine in the guinea-pig aorta. ZM 241385 has a low affinity at A1 receptors. In rat cerebral cortex membranes it displaces tritiated R-phenylisopropyladenosine (R-PIA) with a pIC50 of 5.69. [2]