BEC (hydrochloride)

222638-67-7

C5H13BClNO4S

H2O : >= 35 mg/mL (152.51 mM)

Immunology/Inflammation; Metabolic Enzyme/Protease

BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 uM (ph 7.5). target: Arginase II [1]; In vitro: BEC hydrochloride causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC hydrochloride enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-kappaB DNA binding, and mRNA expression of the NF-kappaB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC hydrochloride increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4]