RG14620

136831-49-7

C14H8Cl2N2

DMSO : >= 26 mg/mL (94.50 mM)

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

RG14620 is an EGFR inhibitor with an IC₅₀ of 3 uM. IC50 & Target: IC50: 3 uM (EGFR)^[1] In Vitro: RG14620 inhibits colony formation (IC₅₀=3 uM) and DNA synthesis (IC₅₀=1 uM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC₅₀=4 uM) and DNA synthesis (IC₅₀=1.25 uM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible^[2]. In Vivo: RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals^[2].