CXCR2-IN-1

1873376-49-8

C19H20Cl2FN3O4S

DMSO : 5.4 mg/mL (11.34 mM; Need ultrasonic and warming)

GPCR/G Protein; Immunology/Inflammation

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC₅₀ of 9.3. IC50 & Target: pIC50: 9.3 (CXCR2)^[1] In Vitro: CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45)^[1]. In Vivo: CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis^[1].