Avexitide

133514-43-9

C149H234N40O47S

H2O : 50 mg/mL (14.84 mM; Need ultrasonic)

GPCR/G Protein

Avexitide (Exendin (9-39)) is a specific and competitive glucagon-like peptide-1 receptor antagonist. In Vitro: GLP-1 plays a role in the control of fasting glucose. Avexitide (Exendin (9-39)), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist in mice and humans. Avexitide (Exendin (9-39)) significantly inhibits amino acid-stimulated insulin secretion in pancreatic islets isolated from neonates with K_ATPHI^[1]. In Vivo: Insulin-to-glucose ratios are significantly lower during Avexitide (Exendin (9-39)) infusion compared with vehicle^[1]. Continuous subcutaneous infusion of Avexitide (Exendin (9-39)) significantly raises fasting blood glucose levels in SUR-1 ^?/? mice without affecting glucose tolerance or insulin sensitivity^[2].