CAY10566

944808-88-2

C18H17ClFN5O2

DMSO : 8 mg/mL (20.52 mM; Need ultrasonic and warming)

Metabolic Enzyme/Protease

CAY10566 is a stearoyl-CoA desaturase1 (SCD1) inhibitor. IC50 & Target: SCD1^[1] In Vitro: CAY10566 (0.0001-10 uM; 24 hours) concentration-dependently decreases Swiss 3T3 cell proliferation^[3]. In Vivo: After establishment of palpable tumors, the mice are treated with vehicle or SCD1 inhibitor (2.5 mg/kg CAY10566 orally twice daily). The effect of SCD1 inhibition on the Akt-driven tumors is greater than on the Ras-driven tumors, with the mean tumor volume at day 13 or 14 post therapy, relative to untreated tumors, 0.5+/-0.04 and 0.67+/-0.05 respectively (P=0.01 for Ras-Akt comparison, by two-tailed t test)^[2].