Warangalone

4449-55-2

C25H24O5

10 mM in DMSO

Stem Cell/Wnt; Protein Tyrosine Kinase/RTK; Anti-infection

Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 ug/mL and 3.7 ug/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 uM. IC50 & Target: IC50: 4.8 ug/mL (3D7), 3.7 ug/mL (K1)^[1]
IC50: 3.5 uM (cAK)^[2] In Vitro: Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 ug/mL and 3.7 ug/mL, respectively^[1]. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 uM^[2]. When HL-60 cells are exposed to Warangalone (30 uM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells^[3].