Mouse Anti-House Dust Mite (HDM) Dermatophagoides pteronyssinus IgM Antibody Assay Kit

ELISA

Gel Packs

Allergic Disease Models / Asthma Models

House dust mite (HDM) is the most common asthma allergen, which affects up to 85% of asthma patients. Of the two main mite species, Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f), more than 20 types of HDM allergens are defined based on sequential and functional homologies. Among those HDM allergens, group 1 (Der 1) and group 2 (Der 2) dominate overall allergic responses in patients and are the most commonly researched allergens. Previously, asthma was considered to be an inflammatory airway disease mediated by the adaptive immune system, particularly type 2 helper T-cells. However, recent studies indicate that the innate immune system is also involved in triggering an inflammatory response in both asthma patients and animal models (8-10). These inflammatory changes and airway remodeling significantly vary depending on the types of allergens. To meet such needs, a mouse HDM-induced asthma model is a useful tool to dissect the pathological roles of the adaptive and innate immune systems activated by different HDM elements. This is an advantage over the classic ovalbumin-induced asthma model which activates adaptive immunity preferentially.

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