CGP005 - HuD (Elavl4) / Paraneoplastic Antigen for detection of anti-Hu antibodies / AUUUA element binding Protein

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.^[1][2]

The HuD/ELAVL4 protein is an RNA-binding protein.^[3]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.^[4][5]

HuD was originaly discovered   as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD   was first used   to assay the presence of anti-Hu antibodies and thereby   diagnose the presence of small cell lung cancer and subacute   sensory neuronopathy. In normal cells , it functions to regulate gene expression and the recombinant protein has been used to identify regualtory elements in mRNA.