Recombinant Human pro-Brain Natriuretic Peptide, glycosylated

Store lyophilized product at -70°C. Afterreconstitution, aliquot and store at -70°C. Avoid multiple freeze/thawcycles.

RecombinantHuman pro-Brain Natriuretic Peptide (proBNP), glycosylated, Molecular weight30 kDa. Does not contain a fusion partner.

Affinity Purified, Lyophilized, Reconstitute in 50mM sodium acetate, pH 4.2 to obtain the sameproBNP concentration prior to lyophilization.

Lot specific (OD280nm, E0.1%= 0.585) (prior to lyophilization)

NPPBnatriuretic peptide B [ Homo sapiens ]

NP_002512

MicroRNAs incardiomyocyte hypertrophy

Brainnatriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP)or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of theheart in response to excessive stretching of heart muscle cells(cardiomyocytes). BNP is named as such because it was originally identifiedin extracts of porcine brain, although in humans it is produced mainly in thecardiac ventricles. BNP is co-secreted along with a 76 amino acid N-terminalfragment (NT-proBNP) which is biologically inactive. BNP binds to andactivates the atrial natriuretic factor receptors NPRA, and to a lesserextent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) butwith 10-fold lower affinity. The biological half-life of BNP, however, istwice as long as that of ANP, and that of NT-proBNP is even longer, makingthese peptides better targets than ANP for diagnostic blood testing.