Recombinant Human pro-Brain Natriuretic Peptide

aliquotand store at -70°C. Avoid multiple freeze/thaw cycles.

Humanpro-Brain Natriuretic Peptide, (proBNP), Recombinant. Immunoreactivity isconfirmed by reaction with monoclonal antibodies specific to differentfragments of proBNP molecule. Predicted molecular mass 12, 036 Da confirmed byMALDI-MS. Contains an additional methionine residue at the N-terminus (incomparison with native proBNP). Also contains one intramolecular disulfidebond between residues Cys87 and Cys103. Does not contain a fusion partner.

Affinity Purified, Liquid

Lot specific

NPPBnatriuretic peptide B [ Homo sapiens ]

NP_002512

MicroRNAs incardiomyocyte hypertrophy

Brainnatriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP)or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of theheart in response to excessive stretching of heart muscle cells(cardiomyocytes). BNP is named as such because it was originally identifiedin extracts of porcine brain, although in humans it is produced mainly in thecardiac ventricles. BNP is co-secreted along with a 76 amino acid N-terminalfragment (NT-proBNP) which is biologically inactive. BNP binds to andactivates the atrial natriuretic factor receptors NPRA, and to a lesserextent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) butwith 10-fold lower affinity. The biological half-life of BNP, however, istwice as long as that of ANP, and that of NT-proBNP is even longer, makingthese peptides better targets than ANP for diagnostic blood testing.