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Recombinant Human HER2/neu (erbB-2)

Recombinant Human HER2/neu (erbB-2)

ArtNr	DAG260
Hersteller	Creative Diagnostics
Menge	20 ug
Kategorie	Oncology Neuroscience Neural Signaling Neural Adhesion Molecules By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Adenocarcinoma Western Blot Astrocytoma By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer Heart & Blood Cancer
Typ	Proteins Recombinant
Format	Lyophilized
Applikationen	WB
Specific against	other
Purity	>95%pure (SDS-PAGE). Two-step procedure using size exclusion chromatographybefore and after refolding. Product is sterile filtered.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	NEU,NGL,HER2,TKR1,CD340,HER-2,MLN 19,HER-2/neu,receptor tyrosine-protein kinaseerbB-2,herstatin,p185erbB2,proto-oncogene Neu,c-erb B2/neu protein,proto-oncogene c-ErbB-2,metastatic lymph node gene 19 protein,tyrosinekinase-type cell surface receptor HER2,neuroblastoma/glioblastoma derivedoncogene homolog
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Manufacturer - Applications	Suitablefor use in Western blot. Each laboratory should determine an optimum workingtiter for use in its particular application. Other applications have not beentested but use in such assays should not necessarily be excluded.
Storage Conditions	Store lyophilized product at -20°C. After reconstitution, aliquot and store at-20°C. Avoid multiple freeze/thaw cycles.
Full name	V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog (Avian)
Product Overview	RecombinantHuman HER2/neu (erbB-2). 43.4kDa protein containing 397 amino acid residuesof the human Herstatin. The amino acid sequence of the recombinant humanherstatin is 100% homologous to the amino acid sequence of the humanherstatin without signal sequence. Does not contain a fusion partner.
Abbr	ERBB2 (Human)
Manufacturer - Format	Purified, Lyophilized, Reconstitute with deionized water to 0.5mg/ml and let thelyophilized pellet dissolve completely (typically requires 20 minutes at37C). For conversion into higher pH values, we recommend intensive dilutionusing a relevant buffer to a concentration of 10ug/ml. In higherconcentrations, the solubility of this antigen is limited.
Buffer	Lyophilized from0.05M Acetate buffer, pH 4
Concentration	0.5mg/ml (prior to lyophilization)
Preservative	None
Gene Information - Gene Name	ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian) [ Homo sapiens ]
Gene Information - mRNA Refseq	NM_001005862
Gene Information - Protein Refseq	NP_001005862
Gene Information - MIM	164870
Gene Information - Pathway	Adherens junction, Alpha6-Beta4 Integrin Signaling Pathway, Calcium signaling pathway, Endometrial cancer, ErbB signaling pathway, Focal Adhesion, Pancreaticcancer, Sema4D in semaphorin signaling, Semaphorin interactions, a6b1 anda6b4 Integrin signaling
Gene Information - Function	ATP binding, ErbB-3class receptor binding, epidermal growth factor-activated receptor activity, protein C-terminus binding, protein heterodimerization activity, proteintyrosine kinase activity, ubiquitin protein ligase binding
Antigen Description	HER2/neu(also known as ErbB-2) stands for Human Epidermal growth factorReceptor 2 and is a protein giving higher aggressiveness in breastcancers. It is a member of the ErbB protein family, more commonly known asthe epidermal growth factor receptor family. HER2/neu has also beendesignated as CD340 (cluster of differentiation 340) and p185. It is encodedby the ERBB2 gene.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 20 ug

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Lieferung vsl. bis 27.11.2025

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