Recombinant Human Glucose-6-Phosphate Dehydrogenase

Store lyophilized product at -20°C. After reconstitution, aliquot and store at-20°C. Avoid multiple freeze/thaw cycles.

Glucose-6-phosphate1-dehydrogenase (G-6-PDH) (Leuconostoc mesenteroides), Recombinant, Molecularweights: 55kDa (SDS-PAGE), 146kDa (gel filtration), was expressed in E. coli.Does not contain a fusion partner.

Purified, Lyophilized

Specific activity:Lot specific IU/mg

G6PDglucose-6-phosphate dehydrogenase [ Homo sapiens ]

NP_000393

Glutathionemetabolism, Metabolic pathways, Metabolism of carbohydrates, PentosePhosphate Pathway, Pentose phosphate pathway (Pentose phosphate cycle)

Glucose-6-phosphate dehydrogenase(G6PD or G6PDH) is a cytosolic enzyme in the pentose phosphate pathway (seeimage), a metabolic pathway that supplies reducing energy to cells (such aserythrocytes) by maintaining the level of the co-enzyme nicotinamide adeninedinucleotide phosphate (NADPH). The NADPH in turn maintains the level ofglutathione in these cells that helps protect the red blood cells againstoxidative damage. Of greater quantitative importance is the production ofNADPH for tissues actively engaged in biosynthesis of fatty acids and/orisoprenoids, such as the liver, mammary glands, adipose tissue, and theadrenal glands.