Recombinant Mouse Interleukin 3 (a. a. 135)

The ED50 asdetermined by the dose-dependent stimulation of mouse M-NFS-60 cells is<0.05ng/ml, corresponding to a specific activity of 2 x 107 IU/mg.Each laboratory should determine an optimum working titer for use in itsparticular application. Other applications have not been tested but use insuch assays should not necessarily be excluded.

Interleukin 3

Il3 (a.a. 135)

Lyophilized fromwater containing no additives

None

NM_010556

Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, IL-3Signaling Pathway, Senescence and Autophagy

Interleukin-3(IL-3) is an interleukin, a type of biological signal (cytokine) that can improvethe body"s natural response to disease as part of the immune system. It actsby binding to the interleukin-3 receptor. IL-3 stimulates the differentiationof multipotent hematopoietic stem cells into myeloid progenitor cells (asopposed to lymphoid progenitor cells where differentiation is stimulated byIL-7) as well as stimulates proliferation of all cells in the myeloid lineage(erythrocytes, megakaryocytes, granulocytes, monocytes, and dendritic cells).It is secreted by basophils and activated T cells to support growth anddifferentiation of T cells from the bone marrow in an immune response. Thehuman IL-3 gene encodes a protein 152 amino acids long, and the naturallyoccurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome5, only 9 kilobases from the GM-CSF gene, and its function is quite similarto GM-CSF.