Recombinant Hepatitis C Virus Core, NS3, NS4, NS5 proteins, His-tagged

Store at -20°C. Avoid multiple freeze/thaw cycles.

Recombinant, Hepatitis C Virus Core antigen, contains, the HCV core, NS3, NS4 and NS5 immunodominant regions of HCV and a 6-His, fusion partner, was expressed in Ecoli. Immunoreactive with HCV positive, sera.

HCV, HCV, NS3+NS4+NS5, Core protein p19, HCV NS4, HCV NS3, HCV NS5, Hepatitis C Virus NS5, NS3P, Hepatitis C Virus nonstructural antigen 4, p27, p8, p70, Serine protease/NTPase/helicase, Flaviviridae, Hepacivirus

Purified, Liquid

3.0mg/ml

HCV, is a positive, single-stranded RNA virus in the Flaviviridae family. The, genome is approximately 10, 000 nucleotides and encodes a single polyprotein, of about 3, 000 amino acids. The polyprotein is processed by host cell and, viral proteases into three major structural proteins including NS3, and, several non-structural proteins necessary for viral replication.The NS3, part of the polyprotein displays three enzymatic activities: serine protease, NTPase and RNA helicase. The NS3 serine proteinase (NS3P) is a non-structural, hepatitis C protein responsible for proteolytic processing of other, non-structural proteins, because of this, it is also the most extensively, studied protein of the Hepatitis C genome. It is responsible for proteolytic, processing of the entire downstream region of the HC polyprotein, catalyzing, cleavage at the NS3/NS4a, NS4a/NS4b, NS4b/NS5a, and NS5a/NS5b sites to, release the mature NS3, NS4a, NS4b, NS5a, and NS5b proteins. For proper, function, NS3 requires NS4a as a cofactor, but, interestingly enough, NS3, also cleaves the NS4a protein. The molecular weight of the monomer NS3P is 70, kDa.