PTGS1 Antibody

PTGS1

COX 1 antibody; COX 3 antibody; COX-1 antibody; COX1 antibody; Cox3 antibody; Cyclooxygenase 1 antibody; Cyclooxygenase 3, included antibody; Cyclooxygenase-1 antibody; EC 1.14.99.1 antibody; Partial COX1 proteins, included antibody; PCOX1 antibody; PGG/HS antibody; PGH synthase 1 antibody; PGH1_HUMAN antibody; PGHS 1 antibody; PGHS-1 antibody; PGHS1 antibody; PHS 1 antibody; PHS1 antibody; Prostaglandin endoperoxide synthase 1 antibody; Prostaglandin G/H synthase 1 antibody; Prostaglandin H2 synthase 1 antibody; Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin-endoperoxide synthase 1 antibody; PTGHS antibody; PTGS1 antibody

Synthesized peptide derived from human COX1.

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

Lawrence M. Szewczuk, J. Biol. Chem., May 2004, 279: 22727 - 22737.
Syed R. Baber, Am J Physiol Heart Circ Physiol, Oct 2005, 289: H1476 - H1487.
Subhashini Chandrasekharan, J. Lipid Res., Dec 2005, 46: 2636 - 2648.
K. Trent Moreland, J. Pharmacol. Exp. T

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunology

Synthesized peptide derived from Human COX1.