TARBP2 Antibody

Polyclonal Antibody

TARBP2

LOQS antibody, Prbp antibody, RISC loading complex subunit TARBP2 antibody, RISC-loading complex subunit tarbp2 antibody, TAR (HIV 1) RNA binding protein 2 antibody, TAR (HIV) RNA binding protein 2 antibody, TAR (HIV) RNA-binding protein TRBP1 antibody, TAR RNA Binding Protein 2 antibody, TAR RNA-binding protein 2 antibody, tarbp2 antibody, TARBP2 RISC loading complex RNA binding subunit antibody, Trans-activation-responsive RNA-binding protein antibody, TRBP antibody, TRBP1 antibody, TRBP2 antibody, TRBP2_HUMAN antibody

Recombinant Human RISC-loading complex subunit TARBP2 protein (1-366AA)

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Antigen Affinity Purified

Microbiology

Recombinant Human RISC-loading complex subunit TARBP2 protein (1-366AA)