USP13 Antibody

Polyclonal Antibody

USP13

Deubiquitinating enzyme 13 antibody, Isopeptidase T 3 antibody, Isopeptidase T-3 antibody, Isopeptidase T3 antibody, ISOT 3 antibody, ISOT-3 antibody, ISOT3 antibody, Ubiquitin carboxyl terminal hydrolase 13 antibody, Ubiquitin carboxyl-terminal hydrolase 13 antibody, Ubiquitin specific peptidase 13 (isopeptidase T3) antibody, Ubiquitin specific peptidase 13 antibody, Ubiquitin specific processing protease 13 antibody, Ubiquitin specific protease 13 antibody, Ubiquitin thioesterase 13 antibody, Ubiquitin thiolesterase 13 antibody, Ubiquitin-specific-processing protease 13 antibody, UBP13 antibody, UBP13_HUMAN antibody, USP 13 antibody, USP13 antibody

Synthesized peptide derived from internal of human USP13.

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro, however, additional experiments are required to confirm such data.

Timms K.M., Gene 217:101-106(1998).
Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Dephoure N., Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from internal of Human USP13.