NBN (Ab-343) Antibody

O60934

ELISA, WB, IHC, WB:1:500-1:1000, IHC:1:50-1:200

WB:1:500-1:1000

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Hsu HL, et al (2005)Oncogene, 24(31): 4956-64.
Falck J, et al. (2005) Nature, 434(7033): 605-11.
Buscemi G, et al. (2004) Oncogene, 23(46): 7691-700.
Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A, 101(33): 12130-5.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Epigenetics and Nuclear Signaling