RPA1 Monoclonal Antibody

Hybridoma Monoclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Purified recombinant human RPA70 protein fragments expressed in E.coli.

Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Epigenetics and Nuclear Signaling

Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair.Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair, it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

Purified recombinant human RPA70 protein fragments expressed in E.coli.