PPARG Antibody

PPARG

CIMT1 antibody; GLM1 antibody; NR1C3 antibody; Nuclear receptor subfamily 1 group C member 3 antibody; OTTHUMP00000185032 antibody; OTTHUMP00000185036 antibody; Peroxisome proliferator activated nuclear receptor gamma variant 1 antibody; Peroxisome proliferator activated receptor gamma 1 antibody; Peroxisome Proliferator Activated Receptor gamma antibody; Peroxisome proliferator-activated receptor gamma antibody; PPAR gamma antibody; PPAR-gamma antibody; PPARG antibody; PPARG_HUMAN antibody; PPARG1 antibody; PPARG2 antibody; PPARgamma antibody

Peptide sequence around aa.50ca.54 (L-S-V-M-E) derived from Human PPARg

Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists."

Mukherjee R., Jow L., Croston G.E., et al. J. Biol. Chem. 272:8071-8076(1997) "Cloning and characterization of RAP250, a nuclear receptor coactivator."
Caira F., Antonson P., Pelto-Huikko M., et al. J. Biol. Chem. 275:5308-5317(2000) "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor a."
Qi C., Chang J., Zhu Y., et al. J. Biol. Chem. 277:28624-28630(2002) "

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Epigenetics and Nuclear Signaling

Peptide sequence around aa.50~54 (L-S-V-M-E) derived from Human PPARg