RAB11FIP2 Antibody

ELISA, WB; WB:1:500-1:3000

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from internal of human RAB11FIP2.

A Rab11 effector binding preferentially phosphatidylinositol 3, 4, 5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.

Nagase T., DNA Res. 6:63-70(1999).
Prekeris R., Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Deloukas P., Nature 429:375-381(2004).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Signal Transduction

Synthesized peptide derived from internal of Human RAB11FIP2.