WDR77 Monoclonal Antibody

Hybridoma Monoclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Purified recombinant human WDR77 protein fragments expressed in E.coli.

Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Signal Transduction

Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones.This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles.Might play a role in transcription regulation.The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Purified recombinant human WDR77 protein fragments expressed in E.coli.