Phospho-IRS1 (Ser639) Antibody

ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:100

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Peptide sequence around phosphorylation site of serine 639 (P-K-S(p)-V-S) derived from Human IRS-1.

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645
Tzatsos A, et al. (2006) Mol Cell Biol, 26(1): 63-76
Steppan CM, et al. (2005) Mol Cell Biol, 25(4): 1569-1575
Batty IH, et al. (2004) Biochem J, 379(Pt 3): 641-651

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Tags & Cell Markers

Peptide sequence around phosphorylation site of serine 639 (P-K-S(p)-V-S) derived from Human IRS-1.