GRIA3 Antibody

Polyclonal Antibody

GRIA3

AMPA 3 antibody, AMPA selective glutamate receptor 3 antibody, AMPA-selective glutamate receptor 3 antibody, dJ1171F9.1 antibody, GluA3 antibody, GLUK3 antibody, GluR 3 antibody, GLUR C antibody, GLUR K3 antibody, GluR-3 antibody, GluR-C antibody, GluR-K3 antibody, GLUR3 antibody, GLURC antibody, Glutamate ionotropic receptor AMPA type subunit 3 antibody, Glutamate receptor 3 antibody, Glutamate receptor C antibody, Glutamate receptor ionotrophic AMPA 3 antibody, Glutamate receptor ionotropic antibody, Glutamate receptor subunit 3 antibody, Glutamate receptor, ionotropic, AMPA 3 antibody, GRIA 3 antibody, Gria3 antibody, GRIA3_HUMAN antibody, Ionotrophic Glutamate Receptor antibody, MRX94 antibody

Recombinant protein of human GRIA3

AMPA- (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Post-transcriptional modifications (alternative splicing and nuclear RNA editing) and post-translational modifications (glycosylation, phoshorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. GluR 3 knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP). In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission. Aberrant GluR 3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Retts syndrome, amyotrophic lateral sclerosis and Alzheimer disease.

Affinity-chromatography purified

Neuroscience

Recombinant protein of Human GRIA3