MMP2 Antibody

Polyclonal Antibody

MMP2

72 kDa gelatinase antibody, 72kD type IV collagenase antibody, CLG 4 antibody, CLG 4A antibody, CLG4 antibody, CLG4A antibody, Collagenase Type 4 alpha antibody, Collagenase type IV A antibody, Gelatinase A antibody, Gelatinase alpha antibody, Gelatinase neutrophil antibody, Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase antibody, Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) antibody, Matrix Metalloproteinase 2 antibody, Matrix metalloproteinase II antibody, Matrix metalloproteinase-2 antibody, MMP 2 antibody, MMP II antibody, MMP-2 antibody, MMP2 antibody, MMP2_HUMAN antibody, MONA antibody, Neutrophil gelatinase antibody, PEX antibody, TBE 1 antibody, TBE-1 antibody

Synthesized peptide derived from human MMP-2.

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2:Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Charlotte J. Morrison, J. Biol. Chem., Dec 2001, 276: 47402 - 47410.
Hala S. Azzam, J Natl Cancer Inst, Nov 1993, 85: 1758 - 1764.
Jane L. English, J. Biol. Chem., Apr 2006, 281: 10337 - 10346.
JORDI ESPARZA, FASEB J, Nov 2004, 18: 1682 - 1691.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cardiovascular

Synthesized peptide derived from Human MMP-2.