TFE3 Antibody

Polyclonal Antibody

TFE3

bHLH e33 antibody, bHLHe33 antibody, Class E basic helix-loop-helix protein 33 antibody, RCCP 2 antibody, RCCP2 antibody, RCCX1 antibody, Renal cell carcinoma, papillary antibody, Tcfe 3 antibody, Tcfe3 antibody, TFE 3 antibody, Tfe3 antibody, TFE3_HUMAN antibody, TFEA antibody, Transcription factor binding to IGHM enhancer 3 antibody, Transcription factor E family, member A antibody, Transcription factor E3 antibody, Transcription factor for IgH enhancer antibody, Transcription factor for immunoglobulin heavy chain enhancer 3 antibody

Peptide sequence around aa.303ca.307 (L-D-V-Y-S) derived from Human TFE3.

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

Clark J., Lu Y.-J., Sidhar S.K., Parker C., Gill S. Oncogene 15:2233-2239(1997) Weterman M.A.J., Wilbrink M., Proc. Natl. Acad. Sci. U.S.A. 93:15294-15298(1996)

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunology

Peptide sequence around aa.303~307 (L-D-V-Y-S) derived from Human TFE3.